NKH477 (hydrochloride)

NKH477 (hydrochloride) (订货以CAS编码或英文名称为准)

腺苷酸环化酶激活剂
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编号:MED17762
分子式:C27H44CLNO8
CAS号:138605-00-2
分子量:546.09
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中文名称: NKH 477
英文名称: NKH477 (hydrochloride)
英文别名: b-Alanine, N,N-dimethyl-,(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-ylester, hydrochloride (1:1);b-Alanine, N,N-dimethyl-,(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-1...;b-Alanine, N,N-dimethyl-,(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pe;NKH 477;NKH 477,N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-ylesterβ-alaninehydrochloride;NKH477 (hydrochloride);6-[3-(dimethylamino)propionyl]-forskolin,Colforsin dapropate hydrochloride,N,N-dimethyl;Adehl;colforsin daropate hydrochloride;colforsindapropatehydrochloride;MKH 477;6-[3-(dimethylamino)propionyl]-forskolin;Colforsin dapropate hydrochloride;N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester b-Alanine hydrochloride
CAS号: 138605-00-2
分子式: C27H44CLNO8
分子量: 546.09
溶解度: H2O: soluble
外观: A solid
储存条件 -20°C

NKH477 (hydrochloride) 是一种新型水溶性毛喉素衍生物,主要通过对舒张性心脏功能的有益作用来改善心力衰竭。 NKH477 直接激活腺苷酸环化酶 (adenylate cyclase) 的催化单元并增加细胞内 cAMP。 NKH477 在体内具有改变的细胞因子谱而发挥抗增殖作用,抑制大鼠原位肺同种异体移植物的急性排斥。

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